June 14, 2018 @ 4:00 pm – 5:00 pm
Dr. Jamie Spangler
“Reshaping the immune response through structure-guided molecular engineering”.
The repertoire of naturally occurring proteins is limited and many molecules induce multiple conflicting effects, impeding their development as therapeutics. Our group leverages structural and mechanistic insights to redesign existing proteins and engineer new proteins that overcome these limitations. We are particularly interested in the discovery and design of antibodies that recruit novel mechanisms for targeted treatment of immune diseases such as cancer, chronic infection, and autoimmune disorders. Synthesizing cutting-edge technologies from structural biophysics, molecular engineering, and translational immunology, we seek new insight into the determinants of protein function in order construct a molecular blueprint for therapeutically biasing immune activity.