August 7, 2024
Evan O’Brien
My lab is interested in studying G-protein coupled receptor (GPCR) structure & dynamics, with an eye towards developing next-gen therapeutics targeting this complex set of receptors. These proteins are pivotal drug targets with extremely complex signaling behaviors. This complexity is […]
July 28, 2022
Chang Liu
WBSB 704Lab website The Liu Lab opened in August 2022. Research Interests We study the molecular mechanisms underlying a variety of nucleic acid transactions, including DNA transposition, RNA synthesis and RNA processing. The current research focus of my laboratory is […]
July 9, 2020
Edward Twomey
Our lab has three main interests. (1) Time-resolved cryo-electron microscopy. How can we understand how proteins work as a function of time? To do this we are developing new techniques for time-resolved specimen preparation in cryo-electron microscopy and cryo-electron tomography. (2) Ionotropic glutamate […]
August 4, 2016
Bin Wu
Research Interest Seeing is believing: my lab is interested in visualizing and quantifying biological events as they happen in situ at real time. We use single molecule imaging and spectroscopy technology in live cells, combined with theoretical modeling to extract […]
February 24, 2016
Cynthia Wolberger
Research Interests Protein function is dynamically regulated in the cell by reversible posttranslational modifications. We are interested in the mechanism by which chromatin modifications regulate transcription, nucleosome dynamics and the response to DNA damage. A particular focus is on the […]
February 24, 2016
Jungsan Sohn
Research Interests We are interested in understanding mechanisms that allow biological stress-sensors to detect danger signals and initiate highly coordinated coping-responses by assembling into higher order molecular assemblies. Innate immunity is the first line of defense against invading pathogens in […]
February 24, 2016
Albert Lau
Research Interests Our lab uses a combination of computational and experimental approaches to try to understand the atomic and molecular details governing the function of protein complexes involved in intercellular communication. The complexes that are studied include ionotropic glutamate receptors […]
February 24, 2016
Dominique Frueh
Research Interests Our laboratory uses nuclear magnetic resonance (NMR) to study modulations of protein dynamics and conformations in active enzymatic systems. Non-ribosomal peptide synthetases (NRPSs) are large enzymatic systems responsible for the biosynthesis of a wealth of secondary metabolites, many […]
February 24, 2016
James M. Berger
Research Interests My laboratory’s research is focused on understanding how multi-subunit assemblies use ATP for overcoming topological challenges within the chromosome and controlling the flow of genetic information. We are particularly interested in developing mechanistic models that explain how macromolecular […]
February 24, 2016
Jie Xiao
Research Interests. single molecule biophysics, super-resolution imaging, cell division, chromosome organization, transcription, gene regulation Research Description. My laboratory focuses on developing novel single-molecule imaging and labeling tools in single cells to study the structures, functions and dynamics of macromolecular assemblies. […]